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Rossetti had strong feelings of guilt after the possible suicide of his wife, Elizabeth Siddal, and that combined with his generally intense nature and sensitivity toward critics and criticism most likely drove him to drink and become addicted to chloral hydrate. He was something of a recluse by the time he died and troubled by paranoia and self-doubts, but he clearly is remembered as both a fine poet and artist. Oliver Reed played Rossetti in Ken Russell's curious 1967 film Dante's Inferno, and Oliver did a great job in Oliver's way, but I think Robert Downey Jr. would make an excellent Rossetti if any new bio-pics happen to be in the works -- and if Robert ever wants to take a break from being Ironman and share some scenes with a wombat or two.
(d.g. rossetti self-portrait from theotherpages.org; snowy wombat courtesy of wikimedia commons)